Comparative Study on Effectiveness of Commercial Antibiotic Discs in Federal Capital Territory (FCT), Nigeria

Clinically, antimicrobial susceptibility testing results provide guidance in the choice of agents patient care. The accuracy from can be affected by multiple factors including media, discs or preparations, inoculum’s size, plate reading and incubation conditions. Misleading test leads to indiscriminate irrational use antibiotics have impacted grossly global challenge resistance. objectives this study were compare efficacy different brands locally foreign manufactured multi-antibiotic on bacteria assess any significant variation. Two each purchased retail stores within FCT. antibacterial Staphylococcus aureus ATCC 25923, Salmonella typhi 9150, Klebsiella pneumonia, Pseudomonas aeruginosa, Bacillus subtilis, Escherichia coli 25922 Streptococcus pyogenes carried out using agar diffusion method. There differences between diameter zones inhibition produced local antibiotic discs. Amoxicillin/clavulanic acid (30 µg) disc highest variation four with range 12.0 – 20.0 mm against organisms. is need for regulatory bodies like NAFDAC SON routinely validate qualities these products market.